down-arrow

The Glacial RxTM Difference

The science

The science

World-recognized scientific founders uncovered and harnessed a previously unknown biological relationship that promises to reshape the way we treat skin conditions.

The treatment

The treatment

The Glacial RxTM treatment is like nothing else on the market. It is truly the next revolution in CryoAestheticsTM.

The research

The research

R2 harnessed this discovery and since 2014 has conducted research and human trials that have resulted in the novel Glacial RxTM system.

Novel impact

Novel impact

Melanin Supression Process

  • Freeze delivered down to melanocytes
  • Ice nucleation impairs transfer of melanin into keratinocytes
  • Epidermal cells turn over with less melanin deposition
  • Cold stress accelerates exfoliation

suppressed melanin

Remove benign lesions by impairing ability of melanocytes to deliver melanin, accelerating exfoliation and normalizing pigment deposition.


suppressed inflammation

Reduce redness and edema plus enhance evenness by suppressing chronic and procedure-related inflammation.


suppressed discomfort

Support delivery of refreshing sensory experience using cooling’s natural analgesic effect.

Globally recognized scientific founders

The team at Blossom Innovations, LLC, and Massachusetts General Hospital seized upon the idea that melanin could be suppressed with cold. They immediately understood that if results could be delivered consistently, cold offered a series of benefits patients and providers would love.

R. ROX ANDERSON, M.D.

R. ROX ANDERSON, M.D.

DIETER MANSTEIN, M.D., PH.D.

DIETER MANSTEIN, M.D., PH.D.

HENRY H. L. CHAN, M.D., PH.D.

HENRY H. L. CHAN, M.D., PH.D.

“Human skin pigmentation is like an ecosystem - a balance among many living cells, interacting and responding to our environment. R2 has shown that softly freezing skin can lighten it and treat some kinds of pigmented lesions.”

- R. Rox Anderson, M.D.

Deeply researched

Never satisfied with good enough, the R2 Technologies team spent years taking an idea
and converting it into a reproducible treatment patients love.

5 contact cooling <br />studies

5 contact cooling
studies

over 600 subjects treated. <br />More added daily

over 600 subjects treated.
More added daily

histology demonstrates <br />melanin suppression and <br/>intact skin architecture

histology demonstrates
melanin suppression and
intact skin architecture

Schedule an introduction

Learn how Glacial RxTM will help your practice
• Attract new patients
• Delegable treatment
• Payback in under 5 months